Biography

Dr Sushma Anand is a Research Fellow at the Centre For Eye Research Australia. Sushma is a highly analytical and detail-oriented biochemist with extensive academic and industry-focused research success, possessing a PhD in Biochemistry and Molecular Biology, coupled with numerous peer-reviewed publications, conference presentations, and awards.

My current research focuses on two main areas within vision sciences: mitochondrial dysfunction in neurodegeneration and optic neuropathies, and the development of novel gene therapies for sight-threatening inherited retinal diseases. One aspect of novelty in my research lies in the utilization of adeno-associated viral vectors for targeted delivery of therapeutic DNA to degenerating retinal cells. This approach offers a precise and efficient means of delivering therapeutic genes to the affected cells, potentially halting, or even reversing vision loss in patients eye diseases. Another innovative aspect of my work involves the development of a cellular model using direct cellular reprogramming to transform human skin cells into neuronallike cells. This model serves as a valuable tool for studying degenerative eye diseases and screening potential neuroprotective drugs. By leveraging this cellular model, we can identify
compounds that may prevent cell death and preserve vision in conditions where current treatments are limited. Furthermore, my research extends beyond the field of vision sciences by exploring the broader applications of cell and gene therapy techniques. For example, the cellular reprogramming technology developed in my lab could potentially be adapted for stimulating the regeneration of affected cells in other organs such as the heart or liver. Overall, my research contributes to the advancement of cell and gene therapy approaches for diseases causing vision loss, with implications for both ocular and systemic health. By addressing the urgent need for improved treatment interventions in this field, my work aims to alleviate the socioeconomic burden associated with vision impairment and enhance quality of life for patients worldwide.

Sushma identifies as culturally and linguistically diverse.

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